Chemical Name: 3-Bromopyridine-2,6-dicarbonitrile Formula: C7H2BrN3 Common Use: Intermediate for pharmaceuticals, agrochemicals Physical Appearance: Off-white to light yellow crystalline powder Odor: Mild or no noticeable smell
Classification: Harmful if swallowed, causes eye and skin irritation, can irritate respiratory tract GH S Label: Exclamation mark pictogram Relevant Hazard Phrases: Harmful in contact with skin or if inhaled, causes serious eye irritation, hazardous to aquatic environment Target Organs: Eyes, skin, respiratory system
Main Component: 3-Bromopyridine-2,6-dicarbonitrile CAS Number: 6816-37-7 Purity: Commonly > 98% in industrial batches Synonyms: 2,6-Dicyano-3-bromopyridine, 3-Bromo-2,6-pyridinedicarbonitrile
Inhalation: Move to fresh air, monitor for breathing difficulty, seek medical attention if symptoms persist Skin Contact: Remove contaminated clothing, wash skin with plenty of soap and water, medical attention may be necessary for persistent irritation Eye Contact: Rinse gently with water for at least 15 minutes, remove contact lenses if present and easy to do, continue rinsing and get medical help if discomfort continues Ingestion: Rinse mouth, never induce vomiting unless instructed by medical personnel, get medical attention Note for Responders: Practice good hygiene, use proper PPE to prevent secondary exposure
Suitable Extinguishing Media: Dry chemical powder, foam, carbon dioxide, water spray Specific Hazards: Emits toxic fumes of nitrogen oxides, hydrogen bromide, and carbon oxides under fire conditions Protective Equipment for Firefighters: Positive pressure self-contained breathing apparatus and full body protection Additional Advice: Evacuate area, avoid inhaling combustion products, contain run-off to prevent contamination
Personal Precautions: Use suitable respirator if dust is generated, avoid skin and eye contact, wear chemical-resistant gloves and goggles Environmental Precautions: Prevent material from entering drains or water sources Methods for Clean-up: Sweep up using non-sparking tools, shovel into suitable container for disposal, ventilate area, wash spill site with soap and water after material removal Waste Disposal: Dispose in compliance with local regulations
Handling: Always operate in well-ventilated workstations, minimize dust generation, ensure local exhaust extraction, use appropriate PPE at all times, avoid ingestion and inhalation Storage: Store in a tightly closed container in a cool, dry, and well-ventilated area, keep away from incompatible substances such as strong oxidizers, acids, and alkalis, segregate from food and feedstuffs, secure containers to prevent tipping
Engineering Controls: Employ local exhaust ventilation, process enclosures, or other engineering controls to keep airborne levels below recommended thresholds Personal Protective Equipment: Safety glasses with side shields or goggles, chemical-resistant gloves (nitrile recommended), lab coats, dust masks or respirators if dust forms Hygiene Measures: Wash hands and face after handling, avoid eating, drinking, or smoking in work areas, remove and wash contaminated clothing before reuse Exposure Limits: No established occupational exposure limits have been identified for this compound, always treat conservatively
Appearance: Off-white/yellowish crystalline powder Odor: Faint or none Melting Point: Approximate range 210-215°C Boiling Point: Data limited, decomposes beyond melting Solubility: Slightly soluble in water, soluble in common organic solvents such as acetone, acetonitrile, DMF Vapor Pressure, Density, pH: Low volatility under ambient conditions, density typical for aromatic heterocycles, no significant aqueous solution pH due to low solubility
Chemical Stability: Maintains stability under standard storage and processing conditions, susceptible to decomposition under high heat or strong sunlight Reactivity: Avoid strong acids, bases, oxidizing agents—possible violent reactions or degradation Hazardous Decomposition Products: Nitrogen oxides, hydrogen bromide, carbon monoxide, and carbon dioxide released under extreme heat or fire
Acute Toxicity: Low acute toxicity anticipated for inhalation and dermal exposure based on limited animal data for this class of compounds, oral intake can cause gastrointestinal discomfort Skin/Eye Irritation: Can cause moderate irritation, repeated contact increases risk Respiratory Effects: Inhalation of dust can cause coughing, throat, and nasal irritation Sensitization: No clear evidence, though routine exposure to many halogenated heterocycles has been associated with mild sensitization in susceptible individuals Chronic Effects: Prolonged exposure data limited, as a manufacturer, regular health surveillance for frequent handlers is prudent
Aquatic Toxicity: Hazardous to aquatic organisms; small spills unlikely to cause widespread harm, but chronic discharge or large accidents threaten local ecosystems Mobility: Poor water solubility suggests limited migration through soil, more persistent in sediment and soil than in open water Degradability: Slow biodegradation expected, potential for accumulation possible Bioaccumulative Potential: Not expected to bioaccumulate signficantly due to molecular structure and physicochemical properties Avoid Releases: Capture and destroy waste streams, apply best practices to keep all process residues out of the environment
Waste Treatment: Incinerate in approved chemical incinerator with afterburner and scrubber or use a licensed chemical waste disposal contractor Waste from Residues/Unused Product: Label and handle as hazardous waste, keep in original container or well-sealed waste drum Container Disposal: Triple rinse containers before recycling or incineration
UN Number: Not assigned for many countries Transportation Class: Generally shipped as non-dangerous unless in large volumes Packing Group: Not typically regulated, but secure packaging is crucial to prevent accidental release Precautions: Protect from physical damage, moisture, and heat during transit
Workplace Regulations: Subject to chemical workplace safety rules—monitor and document worker exposure, ensure safety training Environmental Regulations: Many countries restrict emissions of nitriles and halogenated aromatics; check local laws before disposal or discharge Reporting Requirements: Facilities may need to track and report handling quantities to national or regional authorities
